In medical terms, primary periodic paralysis is referred to as a spectrum of chronic genetic, neuromuscular disorders with autosomal dominant inheritance.3
Primary periodic paralysis is very rare, affecting about 4,000 to 5,000 diagnosed individuals in the United States.4 Although there are related variants, the most common forms are hyperkalemic and hypokalemic PPP.5-9
Paralytic attacks result from loss of muscle membrane excitability10
Clinical attacks vary widely2:
Time between disease onset and diagnosis is often delayed and can take more than 20 years1,2
|May be precipitated by environmental triggers (ie, foods rich in potassium or carbohydrates, rest after exercise, exposure to cold, and emotional stress)1,10,11|
|Acute attacks of flaccid paralysis may be focal or generalized; episodes vary in duration and frequency1,10|
|Symptoms may linger after an attack resolves (ie, clumsiness, extreme fatigue, weakness, palpitations, and pain)1,12|
|As they age, some patients may experience permanent muscle weakness, further impacting their quality of life over time2|
Strongbridge Biopharma sponsored an educational segment about Primary Periodic Paralysis on The Balancing Act, “Behind the Mystery: Rare and Genetic Diseases.” The segment features Linda Feld, Vice President of Periodic Paralysis Association (PPA), and Steve Cannon, MD, PhD, neurologist and professor of physiology at UCLA. A broad range of topics related to Primary Periodic Paralysis are addressed within the segment, including symptoms, triggers, misdiagnosis, and genetic testing.
Uncovering Periodic Paralysis is a no-cost genetic testing program for those who have episodic muscle weakness or temporary paralysis provoked by common triggers for hyperkalemic or hypokalemic periodic paralysis. To learn more, please visit www.uncoveringperiodicparalysis.com. You can also download the patient brochure or HCP brochure.
KEVEYIS® (dichlorphenamide) 50 mg tablets, an oral medication with twice-daily dosing, is indicated for the treatment of13:
What is KEVEYIS?
KEVEYIS (keh-VAY-iss) (dichlorphenamide) is a prescription drug used to treat primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and other similar diseases.
What should you tell your healthcare provider before taking KEVEYIS?
Tell your doctor if you are allergic to dichlorphenamide or other sulfa drugs; if you take high doses of aspirin, or if you have lung or liver disease; if you are pregnant, plan to become pregnant, or are breastfeeding or plan to breastfeed.
What should you know about KEVEYIS?
What are the most common side effects with KEVEYIS?
The most common side effects are a feeling of numbness, tingling or burning (“pins and needles”) in the toes, feet, hands or fingers; trouble with memory or thinking; feeling confused; and unpleasant taste in the mouth.
These are not all of the possible side effects of KEVEYIS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.
© 2018 Strongbridge Biopharma plc
STRONGBRIDGE BIOPHARMA® is a registered trademark of the Strongbridge Biopharma plc. companies, which include Strongbridge Ireland Limited and Strongbridge U.S. Inc.
KEVEYIS® is a registered trademark licensed exclusively in the U.S. to Strongbridge Biopharma plc.
MACRILEN™ is a trademark of Aeterna Zentaris GmbH, licensed exclusively in the U.S. and Canada to Strongbridge Ireland Limited.
MLR-0010 V13 01/2018